Publications

New EuroCLOT Publications

1. Leeds Family Study - heritability of clot structure/function

Previous Publications

TIM SPECTOR

1. de Lange M, Snieder H, Ariens RA, Spector TD, Grant PJ. The genetics of haemostasis: A twin study. Lancet 2001;357(9250):101-5

2. Drayna D, Manichaikul A, de Lange M, Snieder H, Spector TD. Genetic correlates of musical pitch recognition in humans. Science 2001;291:1969-72

3. Jerrard-Dunne et al Ethnic differences in markers of thrombophilia: implications for the investigation of ischemic stroke in multiethnic populations: the South London Ethnicity and Stroke Study. Stroke. 2003 Aug;34(8):1821-6.

4. Snieder H, Hayward CS, Perks U, Kelly RP, Kelly PJ, Spector TD. Heritability of central systolic pressure augmentation: a twin study. Hypertension 2000;35(2):574-9

5. Wilson SG, Reed PW, Bansal A, Chiano M, Lindersson M, Langdown M, Prince RL, Thompson D, Thompson E, Bailey M, Kleyn PW, Sambrook P, Shi MM, Spector TD. Comparison of Genome Screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36. American Journal of Human genetics 2003;72(1):144-155

PETER GRANT

1. Standeven KF, Grant PJ, Carter AM, Scheiner T, Weisel JW, Ariëns RAS. Functional Analysis of the Thr312Ala polymorphism: Effects on fibrin structure and function.Fibrinogen A Circulation 2003; 107:2326-2330.

2. Philippou H, Rance J, Myles T, Hall SW, Ariens RA, Grant PJ, Leung L, Lane DA. Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation: competition for cofactor sites on thrombin determines its fate. J Biol Chem 2003; in press.

3. Lim BCB, Ariëns RAS, Carter AM, Weisel JW, Grant PJ. The genetic regulation of fibrin structure/function: Evidence for complex gene: environment interactions that modulate vascular risk. Lancet 2003; 361: 1424-1431

4. Mills JD, Ariens RAS, Mansfield MW, Grant PJ. Altered fibrin clot structure in the healthy relatives of patients with premature coronary artery disease. Circulation 2002; 106: 1938-1942.

5. Ariëns RAS, de Lange M, Snieder H, Boothby M, Spector TD, Grant PJ. Activation markers of coagulation and fibrinolysis in twins: heritability of the pre-thrombotic state. Lancet 2002; 359: 667-671.

FRITS ROSENDAAL

1. Reiner AP, Heckbert SR, Vos HL, Ariëns RAS, Lemaitre RN, Smith NL, Lumley T, Rea TD, Hindorff LA, Schellenbaum GD, Rosendaal FR, Siscovick DS, Psaty BM. Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of non-fatal myocardial infarction. Blood 2003; 102: 25-30.

2. Dahm A, van Hylckama Vlieg A, Bendz B, Rosendaal FR, Bertina RM, Sandset PM. Low levels of tissue Factor Pathway Inhibitor (TFPI) increase the risk of venous thrombosis. Blood 2003; 101: 4387-92.

3. Doggen CJM, Reiner AP, Vos HL, Rosendaal FR. Two factor XIII gene polymorphisms associated with a structural and functional defect and the risk of myocardial infarction in men. J Thromb Haemost 2003 J Thromb Haemost 2003; 1: 2056-8.

4. Tanis BC, van den Bosch MAAJ, Kemmeren JM, Manger Cats V, Helmerhorst FM, Algra A, van der Graaf Y, Rosendaal FR. Oral contraceptives and the risk of myocardial infarction. N Engl J Med 2001; 345: 1787-1793.

5. Meijers JCM, Tekelenburg WLH, Bouma BN, Bertina RM, Rosendaal FR. High levels of factor XI and the risk of venous thrombosis. N Engl J Med 2000; 342: 696-671.

AARNO PALOTIE

1. Wessman M et al. A Susceptibility for Migraine with aura on chromosome 4q24. Am J Hum Genet 2002;70:652-662.

2. Enattah N et al. Identification of a DNA variant associated with adult type hypolactasia. Nat Genet 2002;30:233-237.

3. Perola M et al. Quantative-Trait-Locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups. Am J Hum Genet 2001;69:117-123.

4. Virolainen E et al. Assignment of a novel locus for autosomal recessive congenital ichthyosis to chromosome 19p13.1-p13.2. Am J Hum Genet 2000;66:1132-1137.

5. Aaltonen J et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997;17:399-403.

ALUN EVANS

1. Blankenberg S, Luc G, Ducimetiere P, Arveiler D, Ferrieres J, Amouyel P, Evans A, Cambien F, Tiret L. Interleukin-18 and the Risk of Coronary Heart Disease in European Men: The Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation. 2003 Oct 27 [Epub ahead of print]

2. Evans AE, van Baal GCM, McCarron P, Patterson CC, et al. The genetics of coronary heart disease: the contribution of twin studies. Twin Res 2003 Oct; 6(5): 432-41.

3. Dallongeville J, Yarnell J, Ducimetiere P, Arveiler D, Ferrieres J, Montaye M, Luc G, Evans A, Bingham A, Hass B, Ruidavets JB, Amouyel P. Fish consumption is associated with lower heart rates. Circulation. 2003 Aug 19;108(7):820-5.

4. Fumeron F, Betoulle D, Nicaud V, Evans A, Kee F, Ruidavets JB, Arveiler D, Luc G, Cambien F. Serotonin transporter gene polymorphism and myocardial infarction: Etude Cas-Temoins de l'Infarctus du Myocarde (ECTIM). Circulation. 2002 Jun 25;105(25):2943-5.

5. Wagner A, Simon C, Evans A, Ferrieres J, Montaye M, Ducimetiere P, Arveiler D. Physical activity and coronary event incidence in Northern Ireland and France: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation. 2002 May 14;105(19):2247-52.

MARIA ANTONIETTA STAZI

1. Stazi M.A., Cotichini R., Patriarca V., Brescianini S., Fagnani C., D'Ippolito C., Cannoni S., Ristori G., Salvetti M.. The Italian Twin Project: from the Personal Identification Number to a National Twin Registry. Twin Res. 2002; 5:382-386.

2. Gaist D, Pedersen N, Koskenvuo M, Bak S, Giampaoli S, Christensen K, Kaprio J Stroke Research in GenomEUtwin. Twin Res. 2003; 6:442-447.

3. C. V. Toschi, M. Arpaia, L. Mussoni, E. Tremoli, S. Colli S. Banfi, M. Camera, G. Giandomenico, Vascular Thrombogenicity induced by progressive LDL oxidation: protection by antioxidants. Thrombosis and Haemostasis 2003; 89:544-553.

4. Baldassarre D, Amato M, Bondioli A, Sirtori CR, Tremoli E. Carotid artery intima-media thickness measured by ultrasonography in normal clinical practice correlates well with atherosclerosis risk factors. Stroke 2000;31:2426-2430.

5. Thomassen L, Brainin M, Demarin V, Grond M, Toni D, Venables GS; EFNS Task Force on Acute Neurological Stroke Care. Acute stroke treatment in Europe: a questionnaire-based survey on behalf of the EFNS Task Force on acute neurological stroke care. Eur J Neurol. 2003 May;10(3):199-204.

NANCY PEDERSEN

1. Beekman, M., Heijmans, B. T., Martin, N. G., Whitfield, J. B., Pedersen, N. L., deFaire, U., Snieder, H., Lakenberg, N., deKnijff, P., Frants, R. R., van Ommen, G. J. B., Kluft, C., Vogler, G., Slagboom, P. E., & Boomsma, D. (2003). Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels. Twin Research, 6(4), 322-324.

2. Iliadou, A., Lichtenstein, P., Morgenstern, R., Forsberg, L., Svensson, R., de Faire, U., Martin, N. G., & Pedersen, N. L. (2002). Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin- angiotensin-aldosterone system. J Hypertens, 20(8), 1543-1550.

3. Lichtenstein, P., deFaire, U., Floderus, B., Svartengren, M., Svedberg, P., & Pedersen, N. L. (2002). The Swedish Twin Registry: A unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine, 252(3), 184-205.

4. Hong, Y., Pedersen, N. L., Egberg, N., & de Faire, U. (1999). Genetic effects for plasma factor VII levels independent of and common with triglycerides. Thrombosis and Haemostasis, 81, 382-386.

5. Hong, Y., Pedersen, N. L., Brismar, K., & de Faire, U. (1997). Genetic and environmental architecture of the features of the insulin-resistance syndrome. American Journal of Human Genetics, 60, 143-152.

JOSE MANUEL SORIA

1. Soria JM, Almasy L, Souto JC, ColI I, Borell M, Mateo J, Stone W , Blangero J, Fontcuberta J. Linkage Analysis demonstrates that the prothrombin G20210A mutation jointly influence plasma prothrombin levels and risk of thrombosis. Blood 95:2780-85.2000.

2. Soria JM, Almasy L, Souto JC, Bacq D, Buil A, Faure A, Martínez-Marchán E, Mateo J, Borell M, Stone WH, Lathrop M, Fontcuberta J, Blangero J. A quantitative trait locus in human factor XII gene jointly influence plasma factor XII levels and susceptibility to thrombotic disease.Am J Hum Genet 70:567-574, 2002.

3. Soria JM , Blangero J, Souto JC, Martinez-Sanchez E, Martinez-Marchan E, Coll I, Tirado I, Cercos A, Almasy L, Fontcuberta L. Identification of a large deletion and three novel mutations in exon 13 of the factor V gene in a Spanish family with normal factor V coagulant and anticoagulant properties.

4. Soria JM, Almasy L, Souto JC, Buil A, Martínez-Sánchez E, Mateo J, Borrell M, Stone W, Lathrop M, Fontcuberta J, Blangero J. A new locus on chromosome 18 that influences normal variation in Activated Protein C Resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility. Blood 101:163-167;2003.

5. Esparza-Gordillo J, Soria JM, Buil A, Souto JC, Almasy L, Blangero J, Fontcuberta J, Rodriguez de Cordoba S. Genetic determinants of variation in the plasma levels of the C4B-binding protein (C4BP) in Spanish families. Immunogenetics 54:862-6;2003.